Blood Purification in Toxicology:​Reviewing the Evidence and Providing Recommendations

gabapentin / pregabalin

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General Recommendation and Indications for ECTR
-In patients severely poisoned with gabapentinoids and normal kidney function, we suggest against performing ECTR in addition to standard care rather than standard care alone (weak recommendation, very low quality of evidence).
-In patients severely poisoned with gabapentinoids and coexisting kidney impairment, we suggest performing ECTR in addition to standard care rather than standard care alone, especially in the presence of associated coma requiring mechanical ventilation (weak recommendation, very low quality of evidence).
 

Type of ECTR
-In patients severely poisoned with gabapentinoids requiring ECTR, when all modalities are available, we recommend using intermittent hemodialysis rather than any other type of ECTR (strong recommendation, very low quality of evidence).
 

Cessation of ECTR
-In patients severely poisoned with gabapentinoids requiring ECTR, we recommend stopping ECTR based on clinical improvement (strong recommendation, very low quality of evidence).​

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Miscellaneous

-If ECTR is performed, patients should be followed closely in an appropriately monitored setting for possible signs and symptoms of withdrawal.