top of page
Blood Purification in Toxicology:Reviewing the Evidence and Providing Recommendations
Barbiturates
General Recommendation
-
ECTR is recommended in severe long-acting barbiturate poisoning (1D)
Indications
ECTR is recommended
-
If prolonged coma is present or expected (1D)
-
If shock is present after fluid resuscitation (1D)
-
If, despite MDAC treatment, toxicity persists (1D)
ECTR is suggested
-
If, despite MDAC treatment, serum barbiturate concentration rises or remains elevated (2D)
-
If respiratory depression necessitating mechanical ventilation is present (2D)
Choice of ECTR
-
Intermittent HD is the preferred mode of ECTR of severe barbiturate poisoning (1D)
-
HP (1D) or CRRT (3D) are acceptable alternative modalities in adults if HD is not available
Cessation of ECTR
-
Cessation of ECTR is indicated when clinical improvement is apparent (1D)
bottom of page